Endocrine Abstracts

Pasireotide is a second-generation, multireceptor-targeted somatostatin receptor ligand and is approved for the treatment of patients with Cushing’s Didease (CD) for whom surgery has failed or is not an option. This retrospective single center study aims to report the efficacy, side effects and follow-up of the treatment with pasireotide alone or in combination with cabergoline in patients without remission after transsphenoidal surgery. Among 187 patients with CD, 15 pat...

Aim: To compare the IGF-1, metabolic and clinical parameters among the ultrasonographically classified NAFLD groups, to examine the effect of weight loss on metabolic parameters and determine the factors that may predict the NAFLD severity in morbidly obese patients who underwent bariatric surgery.Method: This descriptive cross-sectional study was conducted in 316 morbidly obese patients (250 females, 66 males). The data of patients before and 1st year a...

Introduction: Hemichorea-hemiballismus, secondary to hyperglycemia, is a rare but easily treatable condition that is usually associated with poorly controlled type II diabetes mellitus. Diagnosis is based on clinical assessment and imaging. Etiology includes primarily cerebrovascular diseases, metabolic, degenerative, infectious diseases, space-occupying lesions, basal ganglia damage due to drugs and toxic substances.Case: Here we report a rare case of a...

Background: Obesity is a widespread disease that causes chronic low-grade inflammation and related chronic diseases such as steatohepatitis, metabolic syndrome, diabetes mellitus (DM), and cancer. It is known that weight loss positively affects life expectancy by reducing obesity-related complications. Therefore, effective management of particularly morbidly obese patients is getting prominent in clinical practice. Bariatric surgery (BS) is the main effective treatment option ...

Background and aims: MEHMO is an X-linked syndrome comprising Mental retardation, Epilepsy, Hypogenitalism, Microcephaly and Obesity. It is caused by a damaging p.Ile465Serfs frameshift mutation in EIF2S3 that encodes the □ subunit of eukaryotic translation initiation factor 2 (eIF2), essential for protein synthesis and regulation of the integrated stress response. Patients with this EIF2S3 mutation also have neonatal hypoglycemia, early onset insulin-...

This study was carried out to put the Diabetes Health Promotion Self-Care Scale for patients with Type 2 diabetes mellitus (DM) into use for nursing and medical literature. The sample of this methodological design research consisted of 620 patients diagnosed with type 2 DM. The data were collected with Personal Information Form and the Diabetes Health Promotion Self-Care Scale. In the validity and reliability stage of the scale, exploratory and confirmatory factor analyzes, an...

Background: This study aimed to investigate neurocognitive functions and electroencephalography (EEG) parameters in normoglycemic obese children.Method: A total of 73 obese children (38 male and 35 female) and 42 healthy children (21 male and 21 female) were recruited. Biochemical disturbances and insulin resistance (IR) were investigated. The Wechsler Intelligence Scale for Children-Revised (WISC-R) and EEG were performed for all children. Obese partici...

Dipeptidyl peptidase 4 (DPP-4) is thought to play a role in the pathophysiology of metabolic and inflammatory diseases. Increased ADA activity has been suggested to induce insulin resistance and inflammation. We investigated DPP-4 and ADA activities, serum nitric oxide (NO) level and nitric oxide synthase (NOS) activity which are the oxidative stress parameters in patients with PCOS. Fifty two women with PCOS and 41 healthy women were included in this study. Serum ADA activity...

Background: Parathyroid hormone (PTH) is a key regulator of mineral metabolism, the homeostasis of calcium, phospate, vitamin D and bone turnover. Hypoparathyroidism is a rare disease characterized by hypocalceamia with inappropriately low plasma levels of PTH. Mean platelet volume (MPV) is the measure of platelet size. Increased MPV has been associated with cardiovascular risk.Objective: In our preliminary study, we aim to show that untreated hypoparath...

Aplastic anemia is an idiopathic/idiosyncratic or hereditary bone marrow failure characterized by hypocellular bone marrow and pancytopenia without abnormal infiltration and increase in reticulin fibers. Papillary thyroid cancer (PTC) constitutes 85% of all differentiated thyroid cancers. There is no data on the application of radioactive iodine treatment for the treatment of high-risk differentiated thyroid carcinoma detected in the subjects with aplastic anemia.<p class=...